We are beginning to understand the roles of many of the biosynthetic enzymes involved in cell division 1, 2, but little is known as to how they are orchestrated temporally and spatially. This overall simplicity necessitates a complex ensemble of protein players required for the synthesis of cell wall components, acting not only at the appropriate place, but also time, to ensure accurate septation and maintenance of cellular integrity. aureus and other pathogenic microorganisms can provide possibilities for the development of new, more effective treatments for bacterial infections.Ĭell division is a fundamental facet of the bacterial lifecycle whereby the synthesis of a cell wall septum, prior to scission, results in 2 daughter cells. A better understanding of the cell division mechanisms in S. DivIC facilitates the spatial and temporal coordination of peptidoglycan synthesis with the developing architecture of the septum during cell division. Both the function of DivIC and its recruitment to the division site depend on its extracellular domain, which interacts with the cell wall via binding to wall teichoic acids. DivIC spatially regulates peptidoglycan synthesis, and consequently cell wall architecture, by influencing the recruitment to the division septum of the major peptidoglycan synthetases PBP2 and FtsW. Here, we show a distinct, essential role for DivIC in division and survival of Staphylococcus aureus. Central to division is a transmembrane trimeric complex involving DivIB, DivIC and FtsL in Gram-positives.
Many division proteins are highly conserved across bacterial species alluding to a common, basic mechanism. Bacterial cell division is a complex, dynamic process that requires multiple protein components to orchestrate its progression.
0 kommentar(er)
